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Pickens, county, northwestern South Carolina, U.S. It is bounded to the north by North Carolina, to the east by the Saluda River, and to the west by Lakes Jocassee (impounded by the Jocassee Dam), Keowee (impounded by the Keowee Dam), and Hartwell, on the Keowee and Seneca rivers. The county’s northern section lies in rough Blue Ridge Mountains terrain near the southern end of the Appalachian chain and includes Table Rock and Keowee Toxaway state...