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Pascagoula, city, seat (1812) of Jackson county, southeastern Mississippi, U.S. It is situated on Pascagoula Bay of Mississippi Sound (an embayment of the Gulf of Mexico), at the mouth of the Pascagoula River adjacent to Moss Point (north) and Gautier (west), 21 miles (34 km) east of Biloxi. The Gulf Coast settlement developed around a structure called the Old Spanish Fort (which was neither Spanish nor a fort) built in 1718 by the Frenchman Joseph...