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Otsego, county, central New York state, U.S., comprising a rugged upland region bordered by the Unadilla River to the west and the Susquehanna River to the southwest. Originating in Otsego Lake in the northern part of the county, the Susquehanna is one of the longest rivers of the Eastern Seaboard. Other bodies of water include Canadarago Lake and Wharton, Butternut, Otego, Schenevus, and Cherry Valley creeks. Parklands include Glimmerglass and Gilbert Lake state parks. In...