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Osawatomie, city, Miami county, eastern Kansas, U.S. It lies along the Marais des Cygnes River at the mouth of Pottawatomie Creek; its name combines elements of the words Osage and Pottawatomie. Settled in 1854 with support of the New England Emigrant Aid Company, Osawatomie was the headquarters for John Brown’s militant Free State operations in Kansas Territory and was a station on the Underground Railroad (for escaped slaves). At Pottawatomie Creek, Brown and some of...