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Mifflin, county, central Pennsylvania, U.S., consisting of a mountainous region in the Appalachian Ridge and Valley physiographic province. The county is drained by the Juniata River and by Kishacoquillas and Jacks creeks; Honey Creek runs through Reeds Gap State Park. Lewistown, the county seat, was built in 1790 on the site of Ohesson, a Shawnee Indian village; nearby Fort Granville (1755) was destroyed in the French and Indian War (1756). The county was created in...