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Maysville, city, seat (1848) of Mason county, northeastern Kentucky, U.S. It lies at the confluence of Limestone Creek and the Ohio River, there bridged (1931) to Aberdeen, Ohio. The town was established as Limestone in 1787 at the site of a tavern operated (1786–89) by frontiersman Daniel Boone and his wife, Rebecca. It was laid out by Simon Kenton and John May (for whom it was later renamed). By 1792 it had become a landing...