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Manistee, city, seat (1855) of Manistee county, northwestern Lower Peninsula of Michigan, U.S. The city is situated at the mouth of the Manistee River, between Lake Michigan and Manistee Lake, some 85 miles (140 km) north of Muskegon. Built on the river that the Ottawa Indians called Manistee (“Spirit of the Woods”), it was the site of a sawmill erected in 1841 by James and Adam Stronach. It soon became one of the state’s liveliest...