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Lewistown, borough (town), seat (1789) of Mifflin county, south-central Pennsylvania, U.S., on the Juniata River, 45 miles (72 km) northwest of Harrisburg. Opened for settlement (1754) by a treaty with the Iroquois, it was laid out in 1790 on the site of the Shawnee Indian village, Ohesson. It was one of the state’s pioneering iron-manufacturing centres and was named for William Lewis, an early ironmaster. Nearby Fort Granville was built by settlers in 1755 and...