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Harrisburg, city, seat (1859) of Saline county, southern Illinois, U.S. It lies about 40 miles (65 km) east of Carbondale. It was laid out in 1853 and named in honour of James Harris, an attorney who helped establish the community. Coal mining began in 1854 and soon became Harrisburg’s chief industry. The completion of a rail link in 1872 further boosted the coal industry. Lying less than 25 miles (40 km) west of the Ohio...