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Greenville, city, seat (1809) of Darke county, western Ohio, U.S., on Greenville Creek, about 35 miles (55 km) northwest of Dayton. Laid out in 1808, it was the site of Fort Greene Ville, named for Gen. Nathanael Greene and built by Gen. “Mad” Anthony Wayne (1793). After his victory at Fallen Timbers (near the present site of Toledo), Wayne signed a peace treaty at the fort with Indians (1795) that opened the Northwest Territory to...