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Florence, county, east-central South Carolina, U.S. The Great Pee Dee River constitutes its eastern boundary, and the Lynches River part of its western. The county is situated in a low-lying, generally flat area of the Coastal Plain. Lynches River State Park is located in the county, as is the Florence National Cemetery, which contains the graves of Union soldiers and a small group of Confederates. During the American Civil War, Florence, the county seat, became...