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Colleton, county, southern South Carolina, U.S. It is bordered to the southwest by the Salkehatchie River, which at its confluence with the Little Salkehatchie becomes the Combahee River; the Edisto River forms the northern and eastern borders, and a branch of it, the South Edisto, constitutes the southeastern border. At the county’s narrow southern end the Combahee, South Edisto, and Ashepoo rivers empty into the Atlantic Ocean; Edisto Beach State Park is located at the...