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Casa Grande, city, Pinal county, south-central Arizona, U.S. It lies near the Santa Cruz River, 16 miles (26 km) southwest of Casa Grande Ruins National Monument. The city is a health resort in an irrigated agricultural area where cotton, fruit, and alfalfa are raised. Local mines produce copper, silver, and gold. Native American ruins, discovered in 1694 by Jesuit missionary Eusebio Kino, are dominated by the Casa Grande (“Big House”), a four-story adobe watchtower built...