Abraham Lincoln’s vice president Andrew Johnson drank three glasses of whiskey before his 1865 inaugural speech, which he claimed aided in his recovery from a cold. His slurred speech led many in attendance to believe he was drunk, and several senators called for his resignation.

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The Surprisingly Disorderly History of the U.S. Presidential Succession Order

In 1981 U.S. Pres. Ronald Reagan was shot during an assassination attempt. While he was incapacitated in the hospital, Secretary of State Alexander Haig famously declared, “I am in control here.” He also told reporters, “Constitutionally, gentlemen, you have the president, the vice president, and