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Siege of Charleston, (1780) during the American Revolution, British land and sea campaign that cut off and forced the surrender of Charleston, S.C., the principal port city of the southern American colonies. Charleston in 1776 had withstood attack on Fort Sullivan (renamed Fort Moultrie because its defense had been overseen by Gen.William Moultrie) by British naval and army forces commanded by Adm. Peter Parker and Gen. Henry Clinton. In 1779 it repulsed another, led by...