despair

1 despair /dɪˈspeɚ/ noun
1 despair
/dɪˈspeɚ/
noun
Britannica Dictionary definition of DESPAIR
[noncount]
1 
: the feeling of no longer having any hope
2 
: someone or something that causes extreme sadness or worry — + of
2 despair /dɪˈspeɚ/ verb
despairs; despaired; despairing
2 despair
/dɪˈspeɚ/
verb
despairs; despaired; despairing
Britannica Dictionary definition of DESPAIR
[no object]
: to no longer have any hope or belief that a situation will improve or change — often + of