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Erwin Chargaff was a biochemist who made a significant discovery regarding the composition of DNA. In 1950, he found that in DNA, the amount of adenine (A) is always equal to the amount of thymine (T), and the amount of guanine (G) is always equal to the amount of cytosine (C). This observation, known as Chargaff's rules, was crucial for James Watson and Francis Crick in developing their model of the DNA double helix in 1953. Chargaff's findings suggested that adenine pairs with thymine and guanine pairs with cytosine, forming the "rungs" of the DNA ladder structure.12

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