Wuchereria bancrofti

Wuchereria bancrofti is a type of nematode, a threadlike parasitic worm that causes filariasis in humans. This disease is prevalent in tropical and subtropical regions and is transmitted by mosquitoes.1

Cycle of Infection

The infection cycle involves mosquitoes acting as intermediate hosts. Female nematodes produce microscopic larvae called microfilariae, which are ingested by mosquitoes during a blood meal. Inside the mosquito, these larvae develop into infective forms and are then transmitted to humans during subsequent bites. Within about a year, these larvae mature into adult worms, primarily residing in the lymph nodes and vessels of the legs and genital area.1

Symptoms and Treatment

The adult worms can trigger allergic reactions, leading to inflammation, swelling, and impaired circulation. Over time, this can cause the lymph channels to harden and become clogged, resulting in a condition known as elephantiasis, characterized by significant tissue enlargement, particularly in the legs and scrotum. The drug diethylcarbamazine is an effective treatment for filariasis caused by Wuchereria bancrofti.12