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Pre-Columbian civilizations, the Indigenous American urban cultures that developed in Mesoamerica (part of Mexico and Central America) and the Andean region (western South America) prior to Spanish exploration and conquest in the 16th century. The pre-Columbian civilizations were extraordinary developments in human society and culture, ranking with the early civilizations of Egypt, Mesopotamia, and China. Like the ancient urban societies of the Old World, those in the New World were characterized by kingdoms and empires,...