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Why can all truth-functional connectives be defined using the Sheffer stroke?

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In 1913, the American logician Henry M. Sheffer demonstrated that all truth-functional connectives can be defined using a single operator, now known as the Sheffer stroke.1

This is possible because truth-functional connectives are defined by how the truth-value of a complex proposition depends on the truth-values of its components. Since these dependencies can be systematically represented through truth tables, any connective—such as conjunction, disjunction, or the conditional—can be expressed as a combination of other connectives. The Sheffer stroke, which functions as a negated conjunction (often referred to as NAND), provides a sufficient logical basis to reconstruct the truth-functional behavior of all other standard connectives.12