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When was Buenos Aires first founded by Pedro de Mendoza?
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Pedro de Mendoza first founded Buenos Aires in 1536.123
He named the settlement Nuestra Señora Santa María del Buen Aire ("Our Lady St. Mary of the Good Air"). However, the settlement struggled due to deficient supplies and attacks by local Indigenous people, leading the remaining inhabitants to abandon the site in 1541 and move to Asunción. The city was later refounded in 1580 by Juan de Garay.312