When is the radio call sign Air Force One used for a U.S. Air Force aircraft?

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The radio call sign Air Force One is used for any U.S. Air Force aircraft while the president of the United States is on board.12

While the term is often associated in popular culture with the specific, highly modified aircraft reserved for presidential travel—such as the Boeing VC-25A—the call sign is technically applied to any Air Force plane currently transporting the president.12