Must the new pope be chosen from the College of Cardinals?

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No, it is not a formal requirement that the new pope be chosen from the College of Cardinals. While the pope is typically selected from among the cardinals, this is a matter of tradition rather than a strict rule of the Roman Catholic Church.12

The election process, known as the papal conclave, is conducted by the cardinal electors, who must be under the age of 80 to participate. Although the cardinals have historically chosen one of their own to lead the church, any baptized male Catholic is theoretically eligible to be elected as pope.12