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Why were gramicidin and tyrocidin not used for internal infections?
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antimicrobial agent
Iodine, as in the form of Dobell's iodine solution, is an effective antimicrobial agent.
Gramicidin and tyrocidin, which are the primary components of the antibiotic mixture known as tyrothricin, are not used for internal infections because they are toxic to the human body.12
Due to this toxicity, their clinical application is strictly limited to topical use for local infections, particularly those caused by gram-positive bacteria.12