Why is it important that the reaction combining carbon and helium into oxygen is not strongly resonant?

In the context of the anthropic principle, the fact that the reaction combining carbon and helium to form oxygen is not strongly resonant is vital for the existence of life.

While the production of carbon in stars is highly resonant—a "coincidence" that allows carbon to form in sufficient quantities—the subsequent reaction that consumes carbon to create oxygen just fails to be resonant by a narrow margin. If this second reaction were also strongly resonant, the carbon produced in stellar interiors would be rapidly converted into oxygen. Consequently, the supply of carbon necessary to promote biochemistry would be depleted, rendering the formation and persistence of life as we know it impossible.1

These precise energy level alignments are determined by fundamental constants of nature. The delicate balance between these reactions illustrates how the specific values of these constants are essential for the existence of the building blocks of life.1