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Why does reduced pituitary response affect growth hormone release in older adults?

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What causes our skin to wrinkle as we age? — human aging Overview of why skin ages.

In the context of human aging, the reduction in growth hormone (GH) release is linked to changes in the pituitary gland, which serves as a critical connection between the nervous and endocrine systems.1

As individuals age, the pituitary gland exhibits an attenuated response to growth hormone-releasing hormone (GHRH). Because GHRH is the primary stimulus for the synthesis and secretion of growth hormone by the anterior pituitary's somatotroph cells, this diminished sensitivity directly results in a decrease in the overall release of growth hormone. This decline in GH, along with subsequent reductions in insulin-like growth factor 1 (IGF-1) concentrations, contributes to age-related physiological changes, such as the loss of muscle mass and an increase in fat mass.123