Why did Alexander Fleming receive the 1945 Nobel Prize in Physiology or Medicine?

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Alexander Fleming received the 1945 Nobel Prize in Physiology or Medicine for his discovery of penicillin in 1928.12

While Fleming is credited with the initial discovery—having observed that a mold, Penicillium notatum, inhibited the growth of Staphylococcus aureus bacteria—he shared the award with Howard Walter Florey and Ernst Boris Chain. Florey and Chain were recognized for their essential work in isolating and purifying penicillin, which allowed the substance to be developed for general clinical use and successfully applied as a life-saving treatment for bacterial infections.1324

This collaborative effort, which transformed a chance laboratory observation into a medical breakthrough, effectively launched the antibiotic revolution.124