Why are people with active cancer usually not candidates for kidney transplantation?

Individuals with active cancer are generally not considered candidates for kidney transplantation primarily because the immunosuppressive drugs required to prevent organ rejection can suppress the body’s ability to contain or fight the cancer.1

Following a transplant, recipients must take immunosuppressants to inhibit the immune system from attacking the new organ. Because these medications interfere with the body's natural defense mechanisms, they may inadvertently allow existing cancer cells to proliferate or hinder the patient's ability to manage the disease effectively. Consequently, medical professionals prioritize patient safety by avoiding procedures that could exacerbate an active malignancy.123