Which types of microorganisms can the innate immune system defend against?

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The innate immune system provides nonspecific protection against a wide variety of potential pathogens. It is designed to defend the body against diverse microorganisms, including:

This system acts as a first line of defense, utilizing physical barriers like the skin, chemical barriers such as antimicrobial proteins, and specialized cells that target foreign invaders or body cells harboring infectious agents. Because these pathogens are highly diverse, the innate immune system's ability to provide a generalized, nonspecific response is essential for maintaining health and repelling most microorganisms before they cause detectable disease.12