Britannica Sources used in this answer

Which symptoms usually appear first in Ebola virus disease?

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Symptoms of Ebola virus disease typically appear suddenly between 2 and 21 days after exposure. The initial signs of the illness often include:12

  • Fever12
  • Fatigue1
  • Headache12
  • Muscle pain12
  • Sore throat12
  • Loss of appetite2

Because these early symptoms are non-specific, they can often be mistaken for other illnesses such as malaria or influenza, which can make the disease difficult to identify during the initial stages of an outbreak.1