Britannica
Sources used in this answer
Which problems can occur when bone mineralization is impaired during childhood?
Created from Britannica articles
using AI.
AI can make mistakes, so verify using Britannica articles.
bone disease
Defect of tibia, caused by septic osteomyelitis in childhood, with compensatory thickening of the fibula (right). Normal bones are shown at left.
When bone mineralization is impaired during childhood, it primarily leads to rickets, a condition characterized by the softening and deformation of bones. Because the collagen matrix is poorly calcified, the bones become soft and prone to curving.123
Specific problems and symptoms associated with this condition include:
- Skeletal Deformities: Common manifestations include bowlegs, knock-knees, a bulging forehead, and a narrowed chest or pelvis.1
- Growth Issues: Stunted growth and short stature are frequent outcomes.1
- Cartilage Overgrowth: This leads to the enlargement of the ends of long bones and the junction of the ribs with the rib cage, often referred to as the "rachitic rosary".1
- Developmental and Physical Delays: Children may experience a delay in learning to sit, crawl, and walk, as well as delayed eruption of teeth.1
- Muscle and Nerve Symptoms: Lack of muscle tone, restlessness, profuse sweating, and tetany—characterized by muscle spasms, cramps, and twitching—may occur.1