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Which primary teeth are replaced by permanent premolars?

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A labeled cross section illustration of an adult human molar shows the tooth's crown and root, with layers including enamel, dentin, and pulp, as well as gum, cementum, blood vessels, periodontal ligament, lateral canals, and nerve. — tooth Cross section of an adult human molar.

In the human anatomy of the mouth, the primary teeth that are replaced by permanent premolars are the primary molars.1

While the primary dentition consists of 20 teeth—including incisors, canines, and molars—the permanent premolars (also known as bicuspids) specifically succeed the primary molars during the transition to the adult set of 32 teeth. The permanent molars, by contrast, erupt behind the primary teeth and do not replace any of them.1