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Which part of the digestive tract is most often affected by Crohn disease?

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Crohn disease is a chronic inflammatory bowel disease that most often affects the terminal portion of the ileum, which is the region of the small intestine located farthest from the stomach.123

While it typically targets this specific area of the small intestine, the condition can involve other sections of the digestive tract as well. It is characterized by chronic inflammation that can lead to complications such as fistulas, thickening of the intestinal wall, and potential obstruction.312