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Which common diseases have multifactorial inheritance?

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BRCA2 tumor suppressor gene on chromosome 13 — human genetic disease Photomicrograph of the *BRCA2* tumor suppressor gene on chromosome 13 of the human genome. Inactivation of this growth-regulating gene is associated with a higher risk of developing breast cancer.

Multifactorial inheritance refers to disorders caused by the interaction of multiple genes acting in concert with environmental factors. These conditions represent the largest class of inherited disorders in the human population.1

Common diseases associated with multifactorial inheritance include:

Because the specific genetic and environmental triggers for these conditions are often complex or unknown, recurrence risks are typically determined empirically rather than through simple Mendelian ratios. Generally, the risk of recurrence increases based on the number of affected relatives and the closeness of the biological relationship.1