Which cells provide the main output from the corpus striatum?

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The main output of the entire corpus striatum arises from GABAergic cells located in the medial segment of the globus pallidus and in the substantia nigra.1

While the caudate nucleus and putamen (the neostriatum) serve as the receptive components of the corpus striatum, their output is mediated by the axons of medium-size spiny striatal neurons, which project to the globus pallidus and the substantia nigra. From there, the final output to the thalamus is provided by the aforementioned GABAergic cells in the medial pallidal segment and the substantia nigra.1