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Which antibody treatments reduce deaths from Zaire Ebola virus infections?

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Ebolavirus and Ebola virus disease — Ebola Numerous filamentous ebolavirus particles (blue) budding from a chronically-infected VERO E6 cell (yellow-green) in this digitally colorized scanning electron micrograph produced by the U.S. National Institute of Allergy and Infectious Diseases (NIAID).

For infections caused by the Zaire strain of the Ebola virus, two targeted antibody therapies have been shown to help reduce mortality:

REGN-EB3 (marketed as Inmazeb)12
mAb114 (marketed as Ebanga)12

These treatments were approved by the U.S. Food and Drug Administration in 2020 after clinical trials during the 2018–2020 outbreak demonstrated that they were more effective at reducing Ebola-related deaths than other previously investigated options, such as ZMapp and the antiviral drug remdesivir. While these therapies are critical, they are used alongside supportive care—including fluids, electrolytes, and blood pressure stabilization—to manage the disease.12