Where in the lungs does adenocarcinoma usually begin?

Adenocarcinoma of the lung typically originates in the smaller, peripheral bronchi of the lungs.1

These tumors are characterized by cube- or column-shaped cells that form structures resembling glands. While lung tumors can technically begin anywhere in the lung, adenocarcinoma is specifically noted for its peripheral development, distinguishing it from other types like squamous cell carcinoma, which often develops in the larger, central bronchi.1