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Where do B cells mature in the human body?
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immune system
Stimulation of immune response by activated helper T cells. Activated by complex interaction with molecules on the surface of a macrophage or some other antigen-presenting cell, a helper T cell proliferates into two general subtypes, TH1 and TH2. These in turn stimulate the complex pathways of the cell-mediated immune response and the humoral immune response, respectively.
In humans, B cells mature in the bone marrow.12
While all lymphocytes originate from stem cells within the bone marrow, those destined to become B cells remain there to complete their maturation process. This distinguishes them from T cells, which migrate to the thymus to mature. During prenatal development, the fetal liver also serves as a site for B-cell differentiation. Once mature, B cells exit the bone marrow and travel through the bloodstream to secondary lymphoid organs, where they can be activated by antigens.231