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When was the first cholera vaccine used in humans?
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cholera
A woman with cholera being treated by nurses at St. Nicholas Hospital in Saint-Marc, Haiti, 2010.
The first cholera vaccine was used in humans in 1885. During a cholera outbreak in Valencia, Spain, an injectable agent containing a weakened form of the Vibrio cholerae bacterium was administered to help limit the spread of the disease.12
In the decades that followed, researchers developed safer and more effective alternatives, including oral cholera vaccines, which are now preferred for their ability to stimulate immunity directly at the site of bacterial colonization in the gut.12