What symptoms can occur in stage 4 chronic kidney disease?

In stage 4 chronic kidney disease, kidney function is drastically reduced, with an estimated glomerular filtration rate (eGFR) of 15–29. At this stage, the severity of symptoms experienced in earlier stages increases, and several new symptoms may emerge.1

Common symptoms and complications associated with stage 4 chronic kidney disease include:

• General and Neurological: Loss of appetite, nausea, difficulty sleeping, and difficulty concentrating.1
• Systemic Health Issues: The development or worsening of hypertension, bone disease, and heart disease.1
• Existing Symptoms: Symptoms such as edema (swelling in the feet, ankles, and hands), fatigue, foamy urine, and increased urination frequency typically persist and may become more severe.1

It is important to note that chronic kidney disease often progresses significantly before symptoms become apparent, making early diagnosis and management critical. If you are experiencing these symptoms, it is essential to consult a healthcare professional for an accurate evaluation and appropriate care.1