What is systemic lupus erythematosus likely to affect in the body?

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can affect virtually any organ or structure in the body. The disease is characterized by the deposition of immune complexes in tissues, which leads to inflammation and injury.12

While the condition is highly variable and no two individuals experience identical symptoms, it most commonly affects the following areas:1

• Skin: Often manifesting as a butterfly-shaped facial rash, photosensitivity, or discoid lesions.31
• Joints: Frequently causing nondeforming arthritis.31
• Kidneys: Inflammation of the kidneys (glomerulonephritis) is a critical factor in determining the disease's severity and prognosis.31
• Serous Membranes: Inflammation of the linings around the lungs (pleurisy) or the heart (pericarditis).23
• Nervous System: Potential involvement includes psychosis or convulsions.31
• Blood and Circulatory System: Often resulting in anemia, leukopenia, thrombocytopenia, or the formation of blood clots.31
• Other Organs: The gastrointestinal tract and heart may also be affected.1