What happens to a biodegradable scaffold after engineered tissue is implanted?

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In the field of tissue engineering, biodegradable scaffolds serve as a temporary framework upon which cells are seeded to grow and divide into substitute tissues. Once this engineered tissue is implanted into the human body, the scaffold is designed to be gradually absorbed or dissolved by the body. This process allows the newly formed biological tissue to integrate and function at the site of injury or disease as the synthetic or natural support structure disappears.12