What does fibrinoid material in an inflamed blood-vessel wall indicate?

In the context of connective tissue disease, the presence of fibrinoid material in an inflamed blood-vessel wall indicates that portions of the vessel wall have become necrotic, or have died.1

This material is a homogeneous, translucent (hyaline) substance that appears in the walls of blood vessels during certain pathological conditions. It is termed fibrinoid because, when stained with dyes such as eosin, it exhibits tinctorial properties similar to fibrin, the protein responsible for forming the lattice of blood clots. The accumulation of this material is often associated with vasculitis, a common feature of acquired connective tissue diseases that are frequently autoimmune in nature.21