What are the main parts of the brainstem?

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The brainstem is anatomically divided into three primary sections in humans:12

  • Midbrain (mesencephalon): The most superior portion of the brainstem.13
  • Pons (metencephalon): Located beneath the midbrain.32
  • Medulla oblongata (myelencephalon): The most inferior section, which connects to the spinal cord.132

While some anatomical descriptions include the diencephalon—comprising the thalamus, hypothalamus, epithalamus, and subthalamus—as structures rostral to the brainstem, the brainstem itself is specifically defined by these three core regions. Together, these parts serve as a vital communication pathway between the brain and the rest of the body, housing the nuclei for most cranial nerves and regulating essential involuntary functions such as breathing, heart rate, and blood pressure.312