What are Schaffer collaterals and where do they carry information?

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Patient H.M. and short-term memory loss explained — hippocampus Learn about Henry Molaison (better known as “patient H.M.”), whose short-term memory loss following a lobotomy helped researchers to understand how brain structures are related to brain function.

Schaffer collaterals are bundles of axons that serve as a critical component of the hippocampus neural circuitry. Within the trisynaptic circuit, they carry information from the CA3 subregion to the CA1 subregion of the hippocampus.1