Britannica Sources used in this answer

How was halothane used as an inhalation anesthetic?

Created from Britannica articles using AI. AI can make mistakes, so verify using Britannica articles.

Halothane is a potent organohalogen compound that was introduced into medicine in the 1950s as a general anesthetic. As an inhalation anesthetic, it is administered in vapor form.12

Unlike earlier agents such as ether and chloroform, halothane is nonflammable and nonexplosive, which significantly improved safety during surgical procedures. Additionally, its vapors are neither nauseating nor irritating to a patient's mucous membranes.12

Despite these advantages, halothane is known to depress both respiration and circulation. While it became the most frequently used potent anesthetic shortly after its introduction, its use required careful monitoring due to these physiological effects.1