How many untreated people with latent syphilis may progress to tertiary syphilis?

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Scanning electron micrograph of Treponema pallidum, the spirochete bacterium that is the causative agent of syphilis. — syphilis Scanning electron micrograph of *Treponema pallidum*, the spirochete bacterium that is the causative agent of syphilis.

For individuals with untreated latent syphilis, it is estimated that approximately one in four may progress to the final stage of the disease, known as late or tertiary syphilis.1