How is neptunium-237 produced in nuclear reactors?

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Neptunium-237 is produced in nuclear reactors as a by-product of the large-scale production of plutonium. It is synthesized from the reactor fuel uranium-235 and uranium-238 through a process of successive neutron capture and radioactive decay.12

In breeder reactors, for example, approximately one part of neptunium-237 is generated for every 1,000 parts of plutonium produced. Once formed in kilogram quantities, this isotope can be separated from used reactor fuel for scientific study.12