How does the liver process fats in the body?

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The liver plays a central role in lipid metabolism, acting as a hub for the synthesis, processing, and distribution of fats within the body. Its functions include:

  • Bile Production: The liver produces bile, which is essential for the digestion and absorption of dietary fats in the small intestine. Bile salts emulsify fat droplets, allowing enzymes to break them down.12
  • Energy Metabolism: When glucose and glycogen stores are exhausted, the liver converts fatty acids into acetylcoenzyme A (acetyl CoA) to provide energy. During prolonged fasting, the liver performs β-oxidation to produce ketone bodies, which serve as an energy source for the brain.134
  • Lipoprotein Synthesis: The liver synthesizes lipoproteins, such as Very Low-Density Lipoproteins (VLDL), which transport triglycerides and cholesterol to peripheral tissues. It also produces High-Density Lipoproteins (HDL), which collect cholesterol from tissues and return it to the liver for excretion as bile acids and salts.156
  • Storage and Regulation: The liver synthesizes triglycerides for storage when dietary intake of carbohydrates, proteins, or fats exceeds the body's immediate energy requirements.1