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How does the corpus luteum form after ovulation?

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Following ovulation, the corpus luteum forms at the site of the ruptured follicle within the ovary.12

The process occurs as follows:

  • Cellular Transformation: After the follicle releases the ovum, the remaining granulosa and theca cells fill the empty lumen of the follicle.12
  • Luteinization: These cells develop into lutein cells as they accumulate yellow pigment and lipids.1
  • Hormonal Function: The resulting body functions as a temporary hormone-secreting gland, producing significant amounts of progesterone and estrogens.12

This development is regulated by gonadotropins, specifically follicle-stimulating hormone and luteinizing hormone secreted by the pituitary gland. If fertilization does not occur, the corpus luteum becomes inactive and eventually regresses into a scar mass known as a corpus albicans.21